2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

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Chemical Name:2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one
CAS No.:1427579-30-3
Molecular Formula:C₃₇H₃₃N₇O₆
Molecular Weight:671.712
Hs Code.:

2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

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Chemical Property of 2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

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Technology Process of 2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

There total 7 articles about 2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427578-99-1
2-(4-hydroxy-3-methoxyphenyl)-3-(prop-2-yn-1-yl)quinazolin-4(3H)-one

: 1427579-18-7
3-(4-azidobutyl)-2-(4-hydroxy-3-methoxyphenyl)quinazolin-4(3H)-one

: 1427579-30-3
2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm301757v

Reference yield:

: 2-(3-methoxy-4-hydroxyphenyl)-4(3H)-quinazolinone

: 1427579-30-3
2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 2 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 60 °C

4: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 12 h / 20 °C

With pyridine; sodium azide; copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301757v

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 1427579-30-3
2-(4-hydroxy-3-methoxyphenyl)-3-((1-(4-(2-(4-hydroxy-3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogen sulfate / N,N-dimethyl acetamide / 12 h / 145 °C

2: pyridine / dichloromethane / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4: sodium azide / N,N-dimethyl-formamide / 60 °C

5: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 12 h / 20 °C

With pyridine; sodium hydrogen sulfate; sodium azide; copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301757v