3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate

Base Information

• Chemical Name: 3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate
• CAS No.: 1376703-05-7
• Molecular Formula: C₂₉H₃₈ClN₂O₈PS
• Molecular Weight: 641.122
• Mol file: 1376703-05-7.mol

Synonyms:

Chemical Property of 3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate

There total 1 articles about 3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-42-9) → 3-ethyl 5-methyl 2-[(2-{[(diethoxyphosphoryl)(2-thienyl)methyl]amino}ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridenedicarboxylate (1376703-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.17 h / Molecular sieve; Sonication; Reflux

2: tin(II) chloride dihdyrate / 0.33 h / 75 °C / Sonication

With tin(II) chloride dihdyrate; In ethanol; 2: Pudovik reaction;

DOI:10.1002/ardp.201100256

upstream raw materials:

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine