1H-Benzimidazole, 2-[(2,2,2-trifluoroethyl)sulfonyl]-

Base Information

• Chemical Name: 1H-Benzimidazole, 2-[(2,2,2-trifluoroethyl)sulfonyl]-
• CAS No.: 105771-20-8
• Molecular Formula: C9H7F3N2O2S

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Chemical Property of 1H-Benzimidazole, 2-[(2,2,2-trifluoroethyl)sulfonyl]-

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SDS file from LookChem

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Refernces

Benzimidazole derivatives with atypical antiinflammatory activity

10.1021/jm00387a026

This research aimed to investigate the anti-inflammatory activity of substituted 2-[(2,2,2-trifluoroethyl)sulfonyl]-1H-benzimidazoles, a series of compounds with a distinct mechanism from typical cyclooxygenase inhibiting nonsteroidal anti-inflammatory drugs (NSAIDs). The study focused on compounds that showed activity in the rat adjuvant-induced arthritis model but not in the carrageenan paw edema model, suggesting a unique pharmacological profile. The compounds were found to inhibit the release of lysosomal enzymes from neutrophils, indicating a potential anti-inflammatory effect mediated by neutrophil function. Key chemicals used in the synthesis process included various substituted 2-mercaptobenzimidazoles, alkyl iodides, and perfluoroalkyl iodides, along with reagents like m-chloroperoxybenzoic acid for oxidation to sulfones.

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