(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

Base Information

Chemical Name:(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine
CAS No.:863970-00-7
Molecular Formula:C₁₈H₂₀ClNO₃
Molecular Weight:333.815
Hs Code.:

Synonyms:

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Chemical Property of (2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

Chemical Property:

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Technology Process of (2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

There total 11 articles about (2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863969-99-7
(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine-4-carboxylic acid tert-butyl ester

: 863970-00-7
(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

: 2373-88-8,118315-76-7,62174-98-5
ethyl (E)-3-(3-chlorophenyl)prop-2-enoate

: 863970-00-7
(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

Guidance literature:: Multi-step reaction with 11 steps

1.1: 98 percent / DIBAL-H / tetrahydrofuran / 5.5 h / 0 °C

2.1: diethyl L-tartrate; titanium isopropoxide; cumene hydroperoxide / 4 Angstroem molecular sieves / CH₂Cl₂ / 9 h / -35 °C

3.1: aq. NaOH; methyltributylammonium chloride / CH₂Cl₂ / 20 °C

3.2: 65 °C

4.1: Et₃N / ethyl acetate / -20 °C

5.1: Et₃N / ethyl acetate / -20 °C

6.1: aq. HCl / ethyl acetate / -20 - 20 °C

7.1: aq. NaOH; methyltributylammonium chloride / toluene / 20 °C

8.1: propan-2-ol / Heating

9.1: CH₂Cl₂ / 20 °C

10.1: NaH / tetrahydrofuran / 0 - 20 °C

10.2: 1-(p-toluenesulfonyl)imidazole / tetrahydrofuran / 20 °C

11.1: TFA / CH₂Cl₂ / 2 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium hydroxide; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; sodium hydride; diisobutylaluminium hydride; triethylamine; methyl tributylammonium chloride; trifluoroacetic acid; 4 A molecular sieve; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol; toluene; 2.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

: 119125-31-4
(E)-3-(3-chlorophenyl)prop-2-en-1-ol

: 863970-00-7
(2R,3R)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)-methyl]morpholine

Guidance literature:: Multi-step reaction with 10 steps

1.1: diethyl L-tartrate; titanium isopropoxide; cumene hydroperoxide / 4 Angstroem molecular sieves / CH₂Cl₂ / 9 h / -35 °C

2.1: aq. NaOH; methyltributylammonium chloride / CH₂Cl₂ / 20 °C

2.2: 65 °C

3.1: Et₃N / ethyl acetate / -20 °C

4.1: Et₃N / ethyl acetate / -20 °C

5.1: aq. HCl / ethyl acetate / -20 - 20 °C

6.1: aq. NaOH; methyltributylammonium chloride / toluene / 20 °C

7.1: propan-2-ol / Heating

8.1: CH₂Cl₂ / 20 °C

9.1: NaH / tetrahydrofuran / 0 - 20 °C

9.2: 1-(p-toluenesulfonyl)imidazole / tetrahydrofuran / 20 °C

10.1: TFA / CH₂Cl₂ / 2 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium hydroxide; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; sodium hydride; triethylamine; methyl tributylammonium chloride; trifluoroacetic acid; 4 A molecular sieve; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol; toluene; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tetasy.2005.06.012