Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester
CAS No.:129163-75-3
Molecular Formula:C₂₇H₄₅N₂O₆PSi
Molecular Weight:552.723
Hs Code.:

Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

There total 6 articles about Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 129163-74-2
tert-butyldimethylsilyl 2-3-O-benzylidene-β-D-ribofuranoside

: 129163-75-3
Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

Guidance literature:: DOI:10.1016/S0040-4020(01)97590-8

Reference yield:

: 39809-35-3,39809-36-4,78183-65-0
2-3-O-benzylidene-D-ribofuranoside

: 129163-75-3
Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine, DMAP / CH₂Cl₂ / Ambient temperature

2: 83 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

3: 67 percent / trichloroacetic acid / CH₂Cl₂ / 0.5 h

4: 77 percent

With pyridine; 1H-imidazole; dmap; trichloroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)97590-8

Reference yield:

: 50-69-1
D-ribose

: 129163-75-3
Diisopropyl-phosphoramidous acid (3aR,4R,6S,6aR)-6-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / copper sulfate, camphorsulfonic acid / dimethylformamide / 48 h / Ambient temperature

2: 86 percent / pyridine, DMAP / CH₂Cl₂ / Ambient temperature

3: 83 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

4: 67 percent / trichloroacetic acid / CH₂Cl₂ / 0.5 h

5: 77 percent

With pyridine; 1H-imidazole; dmap; copper(I) sulfate; camphor-10-sulfonic acid; trichloroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)97590-8