Technology Process of Pyrazolo[3,4-c]azepine-4-carboxylic acid,
1,2,3,6,7,8-hexahydro-3,6-dioxo-2-phenyl-7-(phenylmethyl)-, methyl
ester
There total 7 articles about Pyrazolo[3,4-c]azepine-4-carboxylic acid,
1,2,3,6,7,8-hexahydro-3,6-dioxo-2-phenyl-7-(phenylmethyl)-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 11 percent / trimethylsilyl iodide / 58 h / Heating
2: 10 percent / methanol / 48 h / Heating
With
trimethylsilyl iodide;
In
methanol;
DOI:10.1071/CH9851847
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetonitrile / 1.5 h / Heating
2: 29 percent / benzene / 6 h / Heating
3: 98 percent / aq. hydrochloric acid / methanol; CHCl3 / 1.5 h / Ambient temperature
4: 10 percent / methanol / 48 h / Heating
With
hydrogenchloride;
In
methanol; chloroform; acetonitrile; benzene;
DOI:10.1071/CH9851847
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / benzene / 24 h / Ambient temperature
2: 72 percent / sodium ethoxide / benzene; ethanol / 6 h / Heating
3: 95 percent / water / acetonitrile / 2.5 h / Heating
4: acetonitrile / 1.5 h / Heating
5: 29 percent / benzene / 6 h / Heating
6: 98 percent / aq. hydrochloric acid / methanol; CHCl3 / 1.5 h / Ambient temperature
7: 10 percent / methanol / 48 h / Heating
With
hydrogenchloride; water; sodium ethanolate;
In
methanol; ethanol; chloroform; acetonitrile; benzene;
DOI:10.1071/CH9851847