Technology Process of (Z)-2-(phenylthio)-3-methyl-4-oxo-6-methyl-2,3,4,5,6,7-hexahydrobenzofuran
There total 5 articles about (Z)-2-(phenylthio)-3-methyl-4-oxo-6-methyl-2,3,4,5,6,7-hexahydrobenzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium fluoride;
In
benzene;
at 80 ℃;
for 8h;
DOI:10.1021/jo01303a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) BuLi, propyl nitrate, 2) aqueous HCl / in THF/hexane, 1) 0 deg C, 45 min., 2) o deg C, 2h, 3) RT, 2h
2: 1) KOH, 2) HOAc / methanol, 1) 1h -10 deg C, 7h 0 deg C, 2) RT, 2h
3: 80 percent / triethylamine, methanesulfonyl chloride / CH2Cl2 / 1) -78 deg C, 5 min., 2) 0 deg C, 3h
4: 52 percent / KF / benzene / 8 h / 80 °C
With
hydrogenchloride; potassium fluoride; potassium hydroxide; n-butyllithium; propyl nitrate; acetic acid; methanesulfonyl chloride; triethylamine;
In
dichloromethane; benzene;
DOI:10.1021/jo01303a005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) KOH, 2) HOAc / methanol, 1) 1h -10 deg C, 7h 0 deg C, 2) RT, 2h
2: 80 percent / triethylamine, methanesulfonyl chloride / CH2Cl2 / 1) -78 deg C, 5 min., 2) 0 deg C, 3h
3: 52 percent / KF / benzene / 8 h / 80 °C
With
potassium fluoride; potassium hydroxide; acetic acid; methanesulfonyl chloride; triethylamine;
In
dichloromethane; benzene;
DOI:10.1021/jo01303a005
