(+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat

Base Information

• Chemical Name: (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat
• CAS No.: 114418-77-8
• Molecular Formula: C₆H₁₄O₁₂P₂
• Molecular Weight: 340.117
• Mol file: 114418-77-8.mol

Synonyms:

Chemical Property of (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat

There total 10 articles about (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3,6-bis-O-(di-O-benzylphospho)-myo-inositol bisphosphate → (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat (2002-56-4,47055-78-7,74465-19-3,107494-29-1,114418-77-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h; under 760 Torr;

Reference yield:

(+/-)-1,2:4,5-di-O-isopropylidene-myo-inositol (51548-88-0,96039-15-5,98974-89-1,128110-25-8) → (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat (2002-56-4,47055-78-7,74465-19-3,107494-29-1,114418-77-8)

Guidance literature:

Multi-step reaction with 4 steps

2: MCPBA

3: 87 percent / aq. HCl / methanol / 0.67 h / Heating

4: 46 percent / H₂ / 10percent Pd/C / aq. ethanol / 12 h / 20 °C / 760 Torr

With hydrogenchloride; hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; ethanol;

Reference yield:

(+/-)-3,6-di-O-allyl-1,2-O-cyclohexylidene-myo-inositol (112204-05-4,149057-08-9) → (+/-)-myo-Inosit-1,4-bis-dihydrogenphosphat (2002-56-4,47055-78-7,74465-19-3,107494-29-1,114418-77-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 5percent aq. NaOH, Bu₄NHSO₄ / CH₂Cl₂ / 24 h / 45 °C

2: NaH / dimethylformamide

3: 0.05 N HCl(MeOH)

4: 97 percent / NaH / dimethylformamide

5: 1,5 cyclooctadiene-bisiridium hexafluorophosphate, H₂ / 1,2-dichloro-ethane

6: 0.1N HCl / methanol; CH₂Cl₂

7: 1H-tetrazole

8: tert-BuOOH

9: 82 percent / 2.5percent CF₃COOH / CH₂Cl₂

10: H₂

With 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; sodium hydroxide; 1,5 cyclooctadiene-bisiridium hexafluorophosphate; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79454-8

upstream raw materials:

(+/-)-2,3,6-tri-O-benzyl-myo-inositol 1,4-bis(dibenzyl phosphate)

1,2:4,5-dicyclohexylidene-myo-inositol

(+/-)-1,2:4,5-di-O-isopropylidene-myo-inositol

(+/-)-3,6-di-O-allyl-1,2-O-cyclohexylidene-myo-inositol