Technology Process of (3S,6S,E)-6-methoxy-3, 5-dimethylnona-4,8-dien-1-ol
There total 5 articles about (3S,6S,E)-6-methoxy-3, 5-dimethylnona-4,8-dien-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3S,6S,E)-6-methoxy-3, 5-dimethylnona-4,8-dien-1-ol; 1-Phenyl-1H-tetrazole-5-thiol;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
With
hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide;
In
ethanol;
at 20 ℃;
for 24h;
DOI:10.1016/j.tetlet.2012.11.015
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 10 - 20 °C
2.1: potassium carbonate; methanol / 0.5 h
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 1 h / 20 °C
4.1: ammonium fluoride / methanol / 12 h / 20 °C
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C
5.2: 24 h / 20 °C
With
methanol; ammonium fluoride; di-isopropyl azodicarboxylate; sodium hydride; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; mineral oil;
1.1: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2012.11.015
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium periodate / tetrahydrofuran; water / 2 h / 0 - 20 °C
2.1: benzene / 3 h / 20 °C
3.1: diisobutylaluminium hydride / toluene; dichloromethane / 2.33 h / -78 - 20 °C / Inert atmosphere
4.1: zinc; ammonium chloride / tetrahydrofuran / 3.25 h / 0 °C
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 10 - 20 °C
6.1: potassium carbonate; methanol / 0.5 h
7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
7.2: 1 h / 20 °C
8.1: ammonium fluoride / methanol / 12 h / 20 °C
9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C
9.2: 24 h / 20 °C
With
methanol; ammonium fluoride; sodium periodate; di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; mineral oil; benzene;
2.1: |Wittig Olefination / 4.1: |Barbier Coupling Reaction / 5.1: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2012.11.015
