[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Base Information

Chemical Name:[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester
CAS No.:179017-53-9
Molecular Formula:C₂₈H₃₇N₂O₆PSi
Molecular Weight:556.671
Hs Code.:

[2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Synonyms:

Suppliers and Price of [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

There total 5 articles about [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146557-69-9
1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine

: 179017-53-9,179017-54-0,197021-47-9
[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / NaBH₄ / ethanol / 20 °C

2: 76 percent / MeP(+)(OPh)3I(-); 2,6-lutidine / dimethylformamide / 20 °C

3: 94 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

4: 87 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

5: 92 percent / Et₃N / aq. ethanol / 20 °C

6: 86 percent / DCC; DMAP / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; chloro-trimethyl-silane; ethanol; MeP(+)(OPh)3I(-); potassium hexamethylsilazane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-12328

Reference yield:

: 146557-80-4
1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine

: 179017-53-9,179017-54-0,197021-47-9
[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / MeP(+)(OPh)3I(-); 2,6-lutidine / dimethylformamide / 20 °C

2: 94 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

3: 87 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

4: 92 percent / Et₃N / aq. ethanol / 20 °C

5: 86 percent / DCC; DMAP / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; dmap; chloro-trimethyl-silane; ethanol; MeP(+)(OPh)3I(-); potassium hexamethylsilazane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-12328

Reference yield:

: 179015-84-0
5'-O-(tert-butydiphenylsilyl)-3'-deoxy-3'-C-(iodomethyl)thymidine

: 179017-53-9,179017-54-0,197021-47-9
[2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

2: 87 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

3: 92 percent / Et₃N / aq. ethanol / 20 °C

4: 86 percent / DCC; DMAP / tetrahydrofuran / 20 °C

With dmap; chloro-trimethyl-silane; ethanol; potassium hexamethylsilazane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1055/s-2001-12328