(S)-5-(4-chlorophenyl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-5-(4-chlorophenyl)pyrrolidin-2-one
CAS No.:1314850-97-9
Molecular Formula:C₁₀H₁₀ClNO
Molecular Weight:195.648
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-(4-chlorophenyl)pyrrolidin-2-one

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Technology Process of (S)-5-(4-chlorophenyl)pyrrolidin-2-one

There total 7 articles about (S)-5-(4-chlorophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₄ClNO₃S

: 1314850-97-9
(S)-5-(4-chlorophenyl)pyrrolidin-2-one

Guidance literature:: C₁₆H₂₄ClNO₃S; With hydrogenchloride; In methanol; at 20 ℃;

With ammonia; ammonium chloride; sodium hydroxide; In water; for 0.166667h; pH=> 11;
DOI:10.1021/jo400164y

Reference yield:

: C₁₅H₂₀ClNO₃

: 1314850-97-9
(S)-5-(4-chlorophenyl)pyrrolidin-2-one

Guidance literature:: With lactam synthase γ expressed in Escherichia coli P329V/A330M variant; In aq. phosphate buffer; at 20 ℃; for 24h; pH=8; enantioselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1126/science.aaw9068

Reference yield:

: 3984-34-7
4-(4-chlorophenyl)-4-oxobutanoic acid

: 1314850-97-9
(S)-5-(4-chlorophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 20 °C

2.1: titanium(IV) tetraethanolate / 72 °C / Inert atmosphere

3.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 2-Amino-2-methyl-1-propanol; potassium tert-butylate / isopropyl alcohol / 50 °C / Molecular sieve

4.1: hydrogenchloride / methanol / 20 °C

4.2: 0.17 h / pH > 11

With hydrogenchloride; titanium(IV) tetraethanolate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sulfuric acid; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; In methanol; isopropyl alcohol;
DOI:10.1021/jo400164y