Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester

Base Information

• Chemical Name: Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester
• CAS No.: 94189-79-4
• Molecular Formula: C₄₄H₄₂N₃O₁₀PS
• Molecular Weight: 835.871
• Mol file: 94189-79-4.mol

Synonyms:

Chemical Property of Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester

There total 3 articles about Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester (94189-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / DDS / pyridine / 5 h / Ambient temperature

2: Et₃N-H₂O-pyridine / 0.67 h / Ambient temperature

With pyridine; water; triethylamine; dapsone; In pyridine;

DOI:10.1016/S0040-4020(01)87448-2

Reference yield:

N4-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine (68892-40-0) → Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester (94189-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / DDS / pyridine / 5 h / Ambient temperature

2: Et₃N-H₂O-pyridine / 0.67 h / Ambient temperature

With pyridine; water; triethylamine; dapsone; In pyridine;

DOI:10.1016/S0040-4020(01)87448-2

Reference yield:

Dithiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (103655-44-3) → Thiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-phenyl ester (94189-79-4)

Guidance literature:

With pyridine; water; triethylamine; for 0.666667h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87448-2

upstream raw materials:

Dithiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

cyclohexylammonium S,S-diphenyl phosphorodithioate

N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine