Technology Process of N-<<1,2,3,3a,4,5,6,8a-octahydro-7-(1-phenylethenyl)-3a-trans-azulenyl>carbonyl>-p-toluenesulfonamide
There total 10 articles about N-<<1,2,3,3a,4,5,6,8a-octahydro-7-(1-phenylethenyl)-3a-trans-azulenyl>carbonyl>-p-toluenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium iodide / dimethylformamide / 17 h / 80 °C
2: 87 percent / LDA / tetrahydrofuran / 2 h / -78 - 20 °C
3: 98 percent / formic acid / 0.1 h / Ambient temperature
4: 100 percent / 2 M tetrabutylammonium fluoride / tetrahydrofuran / 1.) 10 min, 0 deg C; 2.) 30 min, room temperature
5: 92 percent / 1.) NaH / diethyl ether / 1.) reflux, 1 h; 2.) 5 h, room temperature
6: 67 percent / diethyl ether; cyclohexane / 1.) -78 deg C, 1.5 h; 2.) 0 deg C, 3 h
With
formic acid; tetrabutyl ammonium fluoride; sodium hydride; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86638-2
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triethylamine / CH2Cl2 / 1.) 0 deg C; 2.) room temperature, 15 min
2: potassium iodide / dimethylformamide / 17 h / 80 °C
3: 87 percent / LDA / tetrahydrofuran / 2 h / -78 - 20 °C
4: 98 percent / formic acid / 0.1 h / Ambient temperature
5: 100 percent / 2 M tetrabutylammonium fluoride / tetrahydrofuran / 1.) 10 min, 0 deg C; 2.) 30 min, room temperature
6: 92 percent / 1.) NaH / diethyl ether / 1.) reflux, 1 h; 2.) 5 h, room temperature
7: 67 percent / diethyl ether; cyclohexane / 1.) -78 deg C, 1.5 h; 2.) 0 deg C, 3 h
With
formic acid; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86638-2
