5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

Base Information

Chemical Name:5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite
CAS No.:1414882-33-9
Molecular Formula:C₆₀H₆₇N₈O₁₇P
Molecular Weight:1203.21
Hs Code.:

5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

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Chemical Property of 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

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Technology Process of 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

There total 7 articles about 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1414882-32-8
5'-O-dimethoxytrityl-2'-deoxyribofuranosyl-3-guanyl-N,N-bis-[2-(4-nitrophenyl)ethoxycarbonyl]urea

: 108787-34-4
bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

: 1414882-33-9
5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

Guidance literature:: 5'-O-dimethoxytrityl-2'-deoxyribofuranosyl-3-guanyl-N,N-bis-[2-(4-nitrophenyl)ethoxycarbonyl]urea; bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane; With 1H-tetrazole; In dichloromethane; acetonitrile;

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1093/nar/gks706

Reference yield:

: 98495-56-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 1414882-33-9
5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,O-Bis(trimethylsilyl)trifluoroacetamide / dichloromethane / 3 h / Reflux; Inert atmosphere

1.2: 6 h / Reflux; Inert atmosphere

2.1: ammonium hydroxide / 1,4-dioxane; methanol / 20 °C

3.1: pyridine / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran

5.1: pyridine / 20 °C / Darkness

6.1: 1H-tetrazole / dichloromethane; acetonitrile

With 1H-tetrazole; ammonium hydroxide; tetrabutyl ammonium fluoride; N,O-Bis(trimethylsilyl)trifluoroacetamide; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1093/nar/gks706

Reference yield:

: 117399-71-0
β-5',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-5-azacytidine

: 1414882-33-9
5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / 1,4-dioxane; methanol / 20 °C

2: pyridine / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: pyridine / 20 °C / Darkness

5: 1H-tetrazole / dichloromethane; acetonitrile

With 1H-tetrazole; ammonium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1093/nar/gks706