16-methylheptadec-11-yn-1-ol

Base Information

• Chemical Name: 16-methylheptadec-11-yn-1-ol
• CAS No.: 1287709-42-5
• Molecular Formula: C₁₈H₃₄O
• Molecular Weight: 266.467
• Mol file: 1287709-42-5.mol

Synonyms:

Chemical Property of 16-methylheptadec-11-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16-methylheptadec-11-yn-1-ol

There total 5 articles about 16-methylheptadec-11-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

16-methyl-1-[(tetrahydropyran-2-yl)oxy]heptadec-11-yne (1287709-41-4) → 16-methylheptadec-11-yn-1-ol (1287709-42-5)

Guidance literature:

With methanol; toluene-4-sulfonic acid; at 35 ℃; for 48h;

DOI:10.1016/j.chemphyslip.2010.11.006

Reference yield:

1-bromo-10-decanol (53463-68-6) → 16-methylheptadec-11-yn-1-ol (1287709-42-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.03 h / -78 °C / Inert atmosphere

2.2: 24 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 1 h / 0 °C / Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere

5.1: methanol; toluene-4-sulfonic acid / 48 h / 35 °C

With methanol; n-butyllithium; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;

DOI:10.1016/j.chemphyslip.2010.11.006

Reference yield:

1-bromo-10-(tetrahydropyranyloxy)decane (51795-88-1) → 16-methylheptadec-11-yn-1-ol (1287709-42-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.03 h / -78 °C / Inert atmosphere

1.2: 24 h / -78 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / 1 h / 0 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: methanol; toluene-4-sulfonic acid / 48 h / 35 °C

With methanol; n-butyllithium; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;

DOI:10.1016/j.chemphyslip.2010.11.006

upstream raw materials:

16-methyl-1-[(tetrahydropyran-2-yl)oxy]heptadec-11-yne

1-bromo-10-decanol

1-bromo-10-(tetrahydropyranyloxy)decane

1-tetrahydropyranyloxy 11-dodecyne

Downstream raw materials:

(Z)-16-methylheptadec-11-en-1-ol