C₁₅H₁₈N₄O₃

Base Information

• Chemical Name: C₁₅H₁₈N₄O₃
• CAS No.: 1318802-67-3
• Molecular Formula: C₁₅H₁₈N₄O₃
• Molecular Weight: 302.333
• Mol file: 1318802-67-3.mol

Synonyms:

Chemical Property of C₁₅H₁₈N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₈N₄O₃

There total 9 articles about C₁₅H₁₈N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-3-bromoaniline (320337-15-3) → C15H18N4O3 (1318802-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / butan-1-ol

2: n-butyllithium; Trimethyl borate / tetrahydrofuran

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide

4: hydrogen bromide; acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; butan-1-ol; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.05.081

Reference yield:

N-(4-benzyloxy-3-bromophenyl)acetamide (1223466-37-2) → C15H18N4O3 (1318802-67-3)

Guidance literature:

Multi-step reaction with 7 steps

1: dmap; triethylamine

2: water; sodium hydroxide

3: trifluoroacetic acid / dichloromethane

4: triethylamine / butan-1-ol

5: n-butyllithium; Trimethyl borate / tetrahydrofuran

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide

7: hydrogen bromide; acetic acid

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; water; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butan-1-ol; 6: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.05.081

Reference yield:

C20H22BrNO4 → C15H18N4O3 (1318802-67-3)

Guidance literature:

Multi-step reaction with 6 steps

1: water; sodium hydroxide

2: trifluoroacetic acid / dichloromethane

3: triethylamine / butan-1-ol

4: n-butyllithium; Trimethyl borate / tetrahydrofuran

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide

6: hydrogen bromide; acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; water; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butan-1-ol; 5: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.05.081

upstream raw materials:

4-benzyloxy-3-bromoaniline

N-(4-benzyloxy-3-bromophenyl)acetamide

C₂₁H₂₆BrNO₅

C₂₁H₂₈BNO₇

Refernces