(E)-ethyl hexylidene p-isopropylphenylacetic carboxylate

Base Information

• Chemical Name: (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate
• CAS No.: 82234-66-0
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.43
• Mol file: 82234-66-0.mol

Synonyms:

Chemical Property of (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate

There total 3 articles about (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl heptanoate (106-30-9) → (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate (82234-66-0,82234-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA / tetrahydrofuran / 1.) -78 deg C, 40 min, 2.) -78 deg C, 25 min, 3.) room temperature, 1 h

2: 1.) methyllithium / diethyl ether / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

3: phenothiazine / toluene / 14 h / Heating

With 10H-phenothiazine; methyllithium; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

((E)-1-Ethoxy-hept-1-enyloxy)-trimethyl-silane (81171-45-1) → (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate (82234-66-0,82234-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) methyllithium / diethyl ether / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

2: phenothiazine / toluene / 14 h / Heating

With 10H-phenothiazine; methyllithium; In diethyl ether; toluene;

Reference yield:

[2-Chloro-1-ethoxy-2-(4-isopropyl-phenyl)-3-pentyl-cyclopropoxy]-trimethyl-silane → (E)-ethyl hexylidene p-isopropylphenylacetic carboxylate (82234-66-0,82234-67-1) + (Z)-ethyl hexylidene p-isopropylphenylacetic carboxylate (82234-67-1)

Guidance literature:

With 10H-phenothiazine; In toluene; for 14h; Yield given. Yields of byproduct given; Heating;

upstream raw materials:

ethyl heptanoate

((E)-1-Ethoxy-hept-1-enyloxy)-trimethyl-silane

Refernces