Technology Process of Acetic acid 2-(1-acetoxy-3-hydroxy-propyl)-3-benzyloxymethyl-5,7-dimethoxy-6-methyl-1H-indol-4-yl ester
There total 12 articles about Acetic acid 2-(1-acetoxy-3-hydroxy-propyl)-3-benzyloxymethyl-5,7-dimethoxy-6-methyl-1H-indol-4-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 83 percent / LiAlH4, AlCl3
2: 56 percent
3: 1.) Br2, 2.)KOAc / in AcOH
4: 55 percent
5: LiAlH4
6: 92 percent
7: 73 percent
8: 89 percent / N,N-dimethylaniline / 1.25 h / 193 °C
9: 95 percent / Et3N
10: Hg(OAc)2, 90percent HNO3 / acetic anhydride
11: Zn / acetic acid
12: mercuric acetate, sodium bicarbonate / tetrahydrofuran
13: n-Bu4N(1+)F(1-)
With
lithium aluminium tetrahydride; aluminium trichloride; mercury(II) diacetate; tetrabutyl ammonium fluoride; bromine; nitric acid; potassium acetate; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; zinc;
In
tetrahydrofuran; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4039(01)82026-8
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.) Br2, 2.)KOAc / in AcOH
2: 55 percent
3: LiAlH4
4: 92 percent
5: 73 percent
6: 89 percent / N,N-dimethylaniline / 1.25 h / 193 °C
7: 95 percent / Et3N
8: Hg(OAc)2, 90percent HNO3 / acetic anhydride
9: Zn / acetic acid
10: mercuric acetate, sodium bicarbonate / tetrahydrofuran
11: n-Bu4N(1+)F(1-)
With
lithium aluminium tetrahydride; mercury(II) diacetate; tetrabutyl ammonium fluoride; bromine; nitric acid; potassium acetate; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; zinc;
In
tetrahydrofuran; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4039(01)82026-8
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 56 percent
2: 1.) Br2, 2.)KOAc / in AcOH
3: 55 percent
4: LiAlH4
5: 92 percent
6: 73 percent
7: 89 percent / N,N-dimethylaniline / 1.25 h / 193 °C
8: 95 percent / Et3N
9: Hg(OAc)2, 90percent HNO3 / acetic anhydride
10: Zn / acetic acid
11: mercuric acetate, sodium bicarbonate / tetrahydrofuran
12: n-Bu4N(1+)F(1-)
With
lithium aluminium tetrahydride; mercury(II) diacetate; tetrabutyl ammonium fluoride; bromine; nitric acid; potassium acetate; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; zinc;
In
tetrahydrofuran; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4039(01)82026-8
