Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

Base Information

Chemical Name:Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;
CAS No.:133825-26-0
Molecular Formula:CF₃O₃S*C₄₂H₄₆N₃O₄
Molecular Weight:805.915
Hs Code.:

Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

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Chemical Property of Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

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Technology Process of Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

There total 5 articles about Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium; which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133807-76-8
(S)-4,5,6,7-tetrahydro-3-(2-oxo-2-phenylethyl)-3H-imidazo<4.5-c>pyridine-6-carboxylic acid methyl ester dihydrochloride

: 133825-26-0
Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / 1,3-dicyclohexylcarbodiimide, hydroxybenzotriazole*H₂O, EtN(i-Pr)2 / acetonitrile / 48 h / Ambient temperature

2: 1) EtN(i-Pr)2 / 1) CH₂Cl₂, -75 deg C, 15 min, 2a) CH₂Cl₂, -75 deg C to RT, 5h, 2b) RT, 24h

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1002/jhet.5570280118

Reference yield:

: 133807-73-5
(S)-4,5,6,7-tetrahydro-3-(2-oxo-2-phenylethyl)-3H-imidazo<4.5-c>pyridine-6-carboxylic acid hydrochloride hydrobromide

: 133825-26-0
Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

Guidance literature:: Multi-step reaction with 3 steps

1: HCl(g) / methanol / 6 h / Heating

2: 72 percent / 1,3-dicyclohexylcarbodiimide, hydroxybenzotriazole*H₂O, EtN(i-Pr)2 / acetonitrile / 48 h / Ambient temperature

3: 1) EtN(i-Pr)2 / 1) CH₂Cl₂, -75 deg C, 15 min, 2a) CH₂Cl₂, -75 deg C to RT, 5h, 2b) RT, 24h

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1002/jhet.5570280118

Reference yield:

: 133807-77-9
1-(2-oxo-2-phenylethyl)-L-histidine hydrochloride hydrobromide

: 133825-26-0
Trifluoro-methanesulfonate(S)-1-(2-adamantan-1-yl-ethyl)-5-diphenylacetyl-6-methoxycarbonyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-1-ium;

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / 1N HCl / H₂O / 1) RT, 30 min, 2) 2h, reflux

2: HCl(g) / methanol / 6 h / Heating

3: 72 percent / 1,3-dicyclohexylcarbodiimide, hydroxybenzotriazole*H₂O, EtN(i-Pr)2 / acetonitrile / 48 h / Ambient temperature

4: 1) EtN(i-Pr)2 / 1) CH₂Cl₂, -75 deg C, 15 min, 2a) CH₂Cl₂, -75 deg C to RT, 5h, 2b) RT, 24h

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile;
DOI:10.1002/jhet.5570280118