Technology Process of N-Cbz-L-3-carboxy-1,2,3,4-tetrahydroisoquinoline-O-Boc-threonine-OSEM
There total 2 articles about N-Cbz-L-3-carboxy-1,2,3,4-tetrahydroisoquinoline-O-Boc-threonine-OSEM which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / NaHCO3 / H2O / 1.5 h / 20 °C
2: 89 percent / Et3N; DMAP; isopropenyl chloroformate / CH2Cl2 / 1 h / 0 °C
With
dmap; Isopropenyl chloroformate; sodium hydrogencarbonate; triethylamine;
In
dichloromethane; water;
DOI:10.1021/jo0105991
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / NaHCO3 / H2O / 1.5 h / 20 °C
2: 89 percent / Et3N; DMAP; isopropenyl chloroformate / CH2Cl2 / 1 h / 0 °C
With
dmap; Isopropenyl chloroformate; sodium hydrogencarbonate; triethylamine;
In
dichloromethane; water;
DOI:10.1021/jo0105991
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 86 percent / H2 / Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr
2.1: BOP-Cl; NMM / CH2Cl2 / 0.5 h / -15 °C
2.2: 60 percent / NMM / CH2Cl2 / 6 h / 0 °C
3.1: 100 percent / MgBr2*Et2O / CH2Cl2 / 4.5 h / -20 - 0 °C
4.1: 47 percent / NMM; isopropenyl chloroformate / CH2Cl2 / 4 h / -15 - 20 °C
5.1: 83 percent / aq. AcOH / tetrahydrofuran / 16 h
6.1: Dess-Martin periodinane / CH2Cl2 / 2 h
With
4-methyl-morpholine; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; Dess-Martin periodane; acetic acid; magnesium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
6.1: Dess-Martin oxidation;
DOI:10.1021/jo0105991
