C₂₁H₂₈O₄

Base Information

• Chemical Name: C₂₁H₂₈O₄
• CAS No.: 1426055-63-1
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 1426055-63-1.mol

Synonyms:

Chemical Property of C₂₁H₂₈O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₈O₄

There total 15 articles about C₂₁H₂₈O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H18O3 (1426055-62-0) + (benzyloxymethyl)tributylstannane (66222-28-4) → C21H28O4 (1426055-63-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h; diastereoselective reaction;

DOI:10.1055/s-0032-1317693

Reference yield:

((1R,2S,5S)-2-Isopropenyl-5-methyl-cyclohexyl)-acetic acid methyl ester (91975-82-5,114032-14-3) → C21H28O4 (1426055-63-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

3.1: potassium iodide / water; dimethyl sulfoxide / 12 h / 60 °C

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.25 h / 20 °C

6.1: sodium hypochlorite / water; toluene / 6 h / 20 °C

7.1: Trimethyl borate; hydrogen / methanol; dichloromethane; water / 1 h / 20 °C

8.1: triethylamine / dichloromethane / 0.5 h / 0 °C

9.1: IBX*4-methoxypyridine-N-oxide complex

9.2: 10 h / 20 °C

10.1: sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

11.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

With dmap; sodium hypochlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; n-butyllithium; 2-methyl-but-2-ene; Trimethyl borate; IBX*4-methoxypyridine-N-oxide complex; hydroxylamine hydrochloride; hydrogen; sodium acetate; diisobutylaluminium hydride; triethylamine; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; tert-butyl alcohol;

DOI:10.1055/s-0032-1317693

Reference yield:

C12H22O (1426055-55-1) → C21H28O4 (1426055-63-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -78 - 0 °C

2.1: potassium fluoride; 18-crown-6 ether

3.1: dmap

4.1: sodium tetrahydroborate / tetrahydrofuran / 14 h / 20 °C

5.1: p-chlorphenylisocyanate; triethylamine / benzene / 3 h / 20 °C

6.1: Trimethyl borate; hydrogen / methanol; dichloromethane; water / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 °C

8.1: IBX*4-methoxypyridine-N-oxide complex

8.2: 10 h / 20 °C

9.1: sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

10.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

With dmap; potassium fluoride; sodium hypochlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; 18-crown-6 ether; Trimethyl borate; IBX*4-methoxypyridine-N-oxide complex; hydrogen; p-chlorphenylisocyanate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; benzene; 1.1: |Swern Oxidation;

DOI:10.1055/s-0032-1317693

upstream raw materials:

C₁₃H₂₃NO

C₁₃H₂₁NO

C₁₂H₂₀O

((1R,2S,5S)-2-Isopropenyl-5-methyl-cyclohexyl)-acetic acid methyl ester