Technology Process of (2R,3R,4S)-2-iodo-3,4-dimethyl-3-(4-trimethylsilanylbut-3-ynyl)cyclohexanone
There total 4 articles about (2R,3R,4S)-2-iodo-3,4-dimethyl-3-(4-trimethylsilanylbut-3-ynyl)cyclohexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid; sodium iodide;
In
tetrahydrofuran;
for 3h;
cooling;
DOI:10.1021/ol071124k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 3.4 g / pyridinium chlorochromate / CH2Cl2 / 3 h / 20 °C
2.1: magnesium; 1,2-dibromoethane / tetrahydrofuran / 3 h / Heating
2.2: CuI; HMPA / tetrahydrofuran / 0.5 h / -30 °C
2.3: triethylamine / tetrahydrofuran / 16 h / -30 - 20 °C
3.1: 2.6 g / NaI; m-CPBA / tetrahydrofuran / 3 h / cooling
With
magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; sodium iodide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol071124k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium; 1,2-dibromoethane / tetrahydrofuran / 3 h / Heating
1.2: CuI; HMPA / tetrahydrofuran / 0.5 h / -30 °C
1.3: triethylamine / tetrahydrofuran / 16 h / -30 - 20 °C
2.1: 2.6 g / NaI; m-CPBA / tetrahydrofuran / 3 h / cooling
With
magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; sodium iodide;
In
tetrahydrofuran;
DOI:10.1021/ol071124k
