N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide

Base Information

• Chemical Name: N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide
• CAS No.: 1053615-24-9
• Molecular Formula: C₄₂H₅₉FN₆O₈Si₂
• Molecular Weight: 851.135

Synonyms:

Chemical Property of N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide

Chemical Property:

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Safty Information:

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Technology Process of N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide

There total 5 articles about N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide (1053615-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.1 g / imidazole / dimethylformamide / 0.67 h / Ambient temperature

2: CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/P19930000043

Reference yield:

2-N-(phenylacetyl)-9-(β-D-ribofuranosyl)-guanine (132628-16-1) → N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide (1053615-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.1 g / imidazole / dimethylformamide / 0.67 h / Ambient temperature

2: CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/P19930000043

Reference yield:

1-phenylacetoxy-1H-benzotriazole (64656-29-7) → N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenyl-acetamide (1053615-24-9)

Guidance literature:

Multi-step reaction with 3 steps

2: 6.1 g / imidazole / dimethylformamide / 0.67 h / Ambient temperature

3: CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/P19930000043

upstream raw materials:

1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine

2-N-(Phenacetyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

2-N-(phenylacetyl)-9-(β-D-ribofuranosyl)-guanine

Downstream raw materials:

2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-2-N-(phenylacetyl)-5'-O-(9-phenylxanthen-9-yl)guanosine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite>

2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-2-N-(phenylacetyl)-5'-O-(9-phenylxanthen-9-yl)guanosine

2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-2-N-(phenylacetyl)guanosine

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