(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

Base Information

Chemical Name:(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester
CAS No.:1054663-14-7
Molecular Formula:C₂₅H₄₂O₆Si₂
Molecular Weight:494.776
Hs Code.:

(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

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Chemical Property of (3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

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Technology Process of (3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

There total 5 articles about (3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160911-89-7
Methyl <1(R)-(1α,4α,5β)>-5-<<(benzyloxy)methyl>oxy>-4-<<(bromomethyl)dimethylsilyl>oxy>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-cyclohexene-1-carboxylate

: 1054663-14-7
(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 17h; Heating;
DOI:10.1021/jo00102a025

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1054663-14-7
(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

2: 72 percent / MeONa / tetrahydrofuran; methanol / 0.25 h / Ambient temperature

3: 97 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: Bu₃SnH, AIBN / benzene / 17 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00102a025

Reference yield:

: 105539-80-8
methyl<1(R)-(1α,4α,5β)>-4-(benzoyloxy)-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-5-hydroxy-2-cyclohexene-1-carboxylate

: 1054663-14-7
(3aR,5S,7R,7aR)-7-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-benzo[d][1,2]oxasilole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

2: 72 percent / MeONa / tetrahydrofuran; methanol / 0.25 h / Ambient temperature

3: 97 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: Bu₃SnH, AIBN / benzene / 17 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00102a025