(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

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Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester
CAS No.:105997-01-1
Molecular Formula:C₃₀H₃₉F₃O₃
Molecular Weight:504.633
Hs Code.:

(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

There total 10 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105996-96-1,105996-97-2
tert-Butyl-dimethyl-((2S,4aR,4bS,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yloxy)-silane

: 105997-01-1
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq HF / acetonitrile / 1.5 h / Ambient temperature

2: 33 percent / p-TsOH*H₂O / benzene / 1 h / Heating

3: 95 percent / aq HCl / methanol / 0.25 h / Ambient temperature

4: pyridine

With hydrogenchloride; hydrogen fluoride; toluene-4-sulfonic acid; In pyridine; methanol; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)91369-9

Reference yield:

: 105996-89-2
(+/-) - 13-butylthiomethylene-3α-hydroxy-4α,4β,10α-trimethyl-14-oxo-5β,8α,9β-perhydrophenanthrene

: 105997-01-1
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: imidazole / dimethylformamide / 20 h / 25 - 30 °C

2: 1.)NaBH₄ 2.)CdCO₃, HgCl₂ / 1.)EtOH, THF, 2 h, 10 deg C_. 2.)EtOH, reflux, 5 min

3: t-BuOK / benzene; 2-methyl-propan-2-ol / 1 h

4: 1.)n-BuLi / 1.)Hexane, THF, 10 min, 0-5 deg C_. 2.)THF, overnight room temp.

5: aq HF / acetonitrile / 1.5 h / Ambient temperature

6: 33 percent / p-TsOH*H₂O / benzene / 1 h / Heating

7: 95 percent / aq HCl / methanol / 0.25 h / Ambient temperature

8: pyridine

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; cadmium(II) carbonate; hydrogen fluoride; potassium tert-butylate; toluene-4-sulfonic acid; mercury dichloride; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)91369-9

Reference yield:

: 105996-93-8
(+/-) - 3α-t-butyldimethylsilyloxy-13-formyl-4α,4β,10α-trimethyl-1,2,3,4,5β,6,7,8α,9β,10,11,12-dodecahydrophenanthrene

: 105997-01-1
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,4aR,4bS,7R,10aR)-1,1,4a,7-tetramethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthren-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / benzene; 2-methyl-propan-2-ol / 1 h

2: 1.)n-BuLi / 1.)Hexane, THF, 10 min, 0-5 deg C_. 2.)THF, overnight room temp.

3: aq HF / acetonitrile / 1.5 h / Ambient temperature

4: 33 percent / p-TsOH*H₂O / benzene / 1 h / Heating

5: 95 percent / aq HCl / methanol / 0.25 h / Ambient temperature

6: pyridine

With hydrogenchloride; n-butyllithium; hydrogen fluoride; potassium tert-butylate; toluene-4-sulfonic acid; In pyridine; methanol; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)91369-9