(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Name:(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester
CAS No.:80143-18-6
Molecular Formula:C₄₇H₆₁N₅O₁₄
Molecular Weight:920.026
Hs Code.:

(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

There total 2 articles about (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.1%

: 1738-87-0
Z-Leu-ONp

: 57816-11-2,62928-83-0,75283-21-5,76498-06-1,76498-09-4
benzyl 2-acetamido-2-deoxy-3-O-(D-2-propanoyl-L-alanyl-D-isoglutamine benzyl ester)-α-D-glucopyranoside

: 80143-18-6
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1248/cpb.29.2215

Reference yield:

: 71811-18-2
N-acetyl-1-O-benzyl-4,6-O-benzylidene-α-muramyl-α-aminoisobutyryl-D-isoglutamine benzyl ester

: 80143-18-6
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / acetic acid (75percent) / 0.5 h / Heating

2: 41.1 percent / 1-hydroxybenzotriazole, N-ethylmorpholine / dimethylformamide / 16 h / Ambient temperature

With N-ethylmorpholine;; benzotriazol-1-ol; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.2215

Reference yield:

: 80143-18-6
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{1-[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-ethylcarbamoyl]-ethoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

: C₄₄H₆₉N₅O₁₇

Guidance literature:: Multi-step reaction with 2 steps

1: 91.8 percent / hydrogen / palladium black / acetic acid / 3 h / Ambient temperature

2: 61.2 percent / ethylmorpholine / dimethylformamide / 16 h / Ambient temperature

With 2-ethylmorpholine; hydrogen; palladium; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.2215