N-phenylmorpholine-4-carboxamide

Base Information

• Chemical Name: N-phenylmorpholine-4-carboxamide
• CAS No.: 4559-92-6
• Molecular Formula: C11H14 N2 O2
• Molecular Weight: 206.244
• Mol file: 4559-92-6.mol

Synonyms:4-Morpholinecarboxanilide(6CI,7CI,8CI); 4-(N-Phenylcarbamoyl)morpholine; 4-(Phenylcarbamoyl)morpholine;N-Phenyl-4-morpholinecarboxamide; N-[(Phenylamino)carbonyl]morpholine; NSC375995

Chemical Property of N-phenylmorpholine-4-carboxamide

Chemical Property:

• Vapor Pressure: 2.34E-07mmHg at 25°C
• Boiling Point: 422.8°C at 760 mmHg
• Flash Point: 209.5°C
• Density: 1.233g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylmorpholine-4-carboxamide

There total 57 articles about N-phenylmorpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + phenyl isocyanate (103-71-9) → N-phenylmorpholine-4-carboxamide (4559-92-6)

Guidance literature:

at 0 - 20 ℃; for 48.3333h;

DOI:10.3762/bjoc.8.209

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + C12H14N2O4 (1198745-93-5) → N-phenylmorpholine-4-carboxamide (4559-92-6)

Guidance literature:

C₁₂H₁₄N₂O₄; In acetonitrile; at 80 ℃; for 0.5h; Inert atmosphere;

morpholine; In acetonitrile; Inert atmosphere;

DOI:10.1021/ol9023387

Reference yield: 96.0%

N-phenyl-1-morpholinethiocarbamide (15093-54-6) → N-phenylmorpholine-4-carboxamide (4559-92-6)

Guidance literature:

With eosin Y; oxygen; In water; dimethyl sulfoxide; at 20 ℃; for 8h; Schlenk technique; Sealed tube; Irradiation; Green chemistry;

DOI:10.1039/d0gc00070a

upstream raw materials:

morpholine

1,3-diphenylcarbamothioate

phenyl isocyanate

N-ethyl-N'-phenyl-N-o-tolyl-urea

Downstream raw materials:

morpholine

N-ethyl-N'-phenyl-N-o-tolyl-urea

N'-(N-phenyl-morpholine-4-carboximidoyl)-hydrazinecarboxylic acid ethyl ester

C₂₂H₂₆N₄O₃

Refernces

• 1、 Deng, Weiseng,Gan, Ziyu,Jiang, Yuan-Ye,Li, Guoqing,Yan, Qiuli,Yang, Daoshan. "Visible-light-promoted oxidative desulphurisation: A strategy for the preparation of unsymmetrical ureas from isothiocyanates and amines using molecular oxygen". supporting information. p. 2956 - 2962. Retrieved 2020/06/17.
• 2、 Bui, Tien Tan,Kim, Hee-Kwon. "Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines". supporting information. p. 997 - 1002. Retrieved 2020/06/17.