((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester
CAS No.:191597-56-5
Molecular Formula:C₃₄H₄₆F₂N₄O₆
Molecular Weight:644.759
Hs Code.:

((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

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Chemical Property of ((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

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Technology Process of ((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

There total 5 articles about ((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103322-57-2
ethyl 5-phenyl-4(S)-[(N-tert-butoxycarbonyl)amino]-2,2-difluoro-3(R)-hydroxypentanoate

: 191597-56-5
((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / dioxane

2: bis(2-oxo-3-oxazolidinyl)phosphinic chloride, Et₃N

3: 100 percent / 1N aq. NaOH

4: EDCl, HOBt

With hydrogenchloride; sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane;
DOI:10.1016/S0960-894X(98)00131-0

Reference yield:

: 23361-28-6
N-(tert-butyloxycarbonyl)-L-valyl-L-proline

: 191597-56-5
((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: bis(2-oxo-3-oxazolidinyl)phosphinic chloride, Et₃N

2: 100 percent / 1N aq. NaOH

3: EDCl, HOBt

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
DOI:10.1016/S0960-894X(98)00131-0

Reference yield:

: 191597-53-2
(3R,4S)-4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

: 191597-56-5
((S)-1-{(S)-2-[(1S,2R)-1-Benzyl-3-(benzyl-methyl-carbamoyl)-3,3-difluoro-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1N aq. NaOH

2: EDCl, HOBt

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/S0960-894X(98)00131-0