2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester
CAS No.:209340-29-4
Molecular Formula:C₄₆H₆₈O₉Si
Molecular Weight:793.126
Hs Code.:

2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2-Dimethyl-propionic acid (3S,5S)-3-benzyloxy-6-{2-[(2S,4S)-4-benzyloxy-2-hydroxy-6-(4-methoxy-phenoxy)-hexyl]-[1,3]dithian-2-yl}-5-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexyl ester

: 209340-29-4
2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

Guidance literature:: With mercury(II) perchlorate; calcium carbonate; In tetrahydrofuran; water; at 0 ℃; for 0.166667h; Yield given;
DOI:10.1016/S0040-4039(98)00619-4

Reference yield:

: 209340-29-4
2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

: 2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-5-(tert-butyl-dimethyl-silanyloxy)-3,9,11-trihydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 14h; Ambient temperature;
DOI:10.1016/S0040-4039(98)00619-4

Reference yield:

: 209340-29-4
2,2-Dimethyl-propionic acid (3S,5S,9S,11S)-3,11-bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-13-(4-methoxy-phenoxy)-5-methyl-7-oxo-tridecyl ester

: 2-{(2S,4S,6R,8S,10S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-[2-(4-methoxy-phenoxy)-ethyl]-4-methyl-10-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate / 14 h / Ambient temperature

2: CAS / CH₂Cl₂; methanol / 1 h / Ambient temperature

3: imidazole / dimethylformamide / 1 h / Ambient temperature

4: DIBALH / CH₂Cl₂ / 0.17 h / -78 °C

With 1H-imidazole; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00619-4