6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone

Base Information

• Chemical Name: 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
• CAS No.: 11005-80-4
• Molecular Formula: C₅₄H₉₀N₆O₁₈
• Molecular Weight: 1111.34
• Mol file: 11005-80-4.mol

Synonyms:

Chemical Property of 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone

There total 10 articles about 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Hiv-D-Val-L-Lac-L-Val-SNAC → valinomycin (2001-95-8,11005-80-4)

Guidance literature:

With recombinant terminal CesB thioesterase; In aq. buffer; at 22 ℃; for 14h; pH=7.4; Enzymatic reaction;

DOI:10.1021/acs.jnatprod.0c00333

Reference yield:

TFA.(D-Val-Lac-Val-D-Hyv)3-OH (126784-73-4) → valinomycin (2001-95-8,11005-80-4)

Guidance literature:

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81083-8

Reference yield:

Boc-(D-Val-Lac-Val-D-Hyv)3-OH → valinomycin (2001-95-8,11005-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h

2: 107 mg / BOP, TEA / CH₂Cl₂ / 48 h / Ambient temperature

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane;

DOI:10.1016/S0040-4020(01)81083-8

upstream raw materials:

TFA_.(D-Val-Lac-Val-D-Hyv)3-OH

D-valyl->L-2-hydroxy-propionyl->D-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->D-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->D-valyl->D-2-hydroxy-3-methyl-butyric acid; hydrobromide

D-valyl->L-2-hydroxy-propionyl->D-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyric acid; hydrobromide

D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->D-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyric acid; hydrobromide

Downstream raw materials:

(3S,6S)-3-isopropyl-6-methyl-morpholine-2,5-dione