Technology Process of (6S,7R,8S)-(-)-7-epi-goniodiol
There total 6 articles about (6S,7R,8S)-(-)-7-epi-goniodiol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-6-((2S,3S)-3-phenyloxiran-2-yl)-5,6-dihydro-2H-pyran-2-one;
With
perchloric acid; water;
for 1h;
With
sodium hydrogencarbonate;
In
water;
at 20 ℃;
Overall yield = 94 %;
DOI:10.1021/acs.jnatprod.6b00386
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane
2.1: perchloric acid; water / 1 h
2.2: 20 °C
With
perchloric acid; water; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1021/acs.jnatprod.6b00386
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: titanium tetrachloride; titanium(IV) isopropylate; silver(l) oxide; (S)-2,2'-dihydroxy-1,1'-binaphthyl / dichloromethane / 48 h / -15 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 2 h / 0 °C
3.1: Grubbs catalyst first generation / dichloromethane / 6 h / Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane
5.1: perchloric acid; water / 1 h
5.2: 20 °C
With
(S)-2,2'-dihydroxy-1,1'-binaphthyl; Grubbs catalyst first generation; titanium(IV) isopropylate; perchloric acid; water; titanium tetrachloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide;
In
dichloromethane;
DOI:10.1021/acs.jnatprod.6b00386
