2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone

Base Information

• Chemical Name: 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone
• CAS No.: 15707-19-4
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.251
• Mol file: 15707-19-4.mol

Synonyms:

Chemical Property of 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone

There total 1 articles about 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethyl-pyrazine (123-32-0) + benzoic acid ethyl ester (93-89-0,99341-95-4) → 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone (15707-19-4) + C13H12N2O (78605-12-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Reflux;

DOI:10.1021/ol202819w

Reference yield:

carbonic acid (E)-4-bromobut-2-en-1-yl methyl ester + 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone (15707-19-4) → C19H20N2O4 (1639441-10-3)

Guidance literature:

2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

carbonic acid (E)-4-bromobut-2-en-1-yl methyl ester; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201404286

Reference yield:

carbonic acid (E)-4-bromobut-2-en-1-yl methyl ester + 2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone (15707-19-4) → C19H20N2O4

Guidance literature:

2-(5-methyl-pyrazin-2-yl)-1-phenyl-ethanone; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

carbonic acid (E)-4-bromobut-2-en-1-yl methyl ester; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.5b10440

upstream raw materials:

2,5-dimethyl-pyrazine

benzoic acid ethyl ester

Downstream raw materials:

C₁₉H₂₀N₂O₄

C₁₇H₁₆N₂O