3β-methoxyandrost-5-ene-17-one

Base Information

• Chemical Name: 3β-methoxyandrost-5-ene-17-one
• CAS No.: 56085-46-2
• Molecular Formula: C₂₀H₃₀O₂
• Molecular Weight: 302.457
• Mol file: 56085-46-2.mol

Synonyms:

Chemical Property of 3β-methoxyandrost-5-ene-17-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3β-methoxyandrost-5-ene-17-one

There total 2 articles about 3β-methoxyandrost-5-ene-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cholesteryl methyl ether (1174-92-1) → Androsta-1,4-diene-3,17-dione (897-06-3) + 3β-methoxyandrost-5-ene-17-one (56085-46-2,10457-69-9)

Guidance literature:

With potassium dihydrogenphosphate; D-glucose; magnesium sulfate; ammonium chloride; iron(II) sulfate; urea; citric acid; calcium carbonate; at 28 - 30 ℃; for 92h; pH=6.8 - 7.2; Microbiological reaction;

DOI:10.1007/s11172-019-2711-0

Reference yield:

cholesteryl methyl ether (1174-92-1) → Androstenedione (63-05-8) + 3β-methoxyandrost-5-ene-17-one (56085-46-2,10457-69-9)

Guidance literature:

With potassium dihydrogenphosphate; D-glucose; magnesium sulfate; ammonium chloride; iron(II) sulfate; urea; citric acid; calcium carbonate; at 28 - 30 ℃; for 92h; pH=6.8 - 7.2; Reagent/catalyst; Microbiological reaction;

DOI:10.1007/s11172-019-2711-0

Reference yield:

3β-methoxyandrost-5-ene-17-one (56085-46-2,10457-69-9) → (20 R)-3β-methoxy-17α-(phenylseleno)-5-cholen-24,20-lactone (96838-03-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Li / 1.) ether, 0deg C, 2 h; 2.) ether, THF, 0 deg C, 2 h, r.t., 12 h

2: 1.12 g / propionic acid / 6 h / 135 - 145 °C

3: 99 percent / KOH / methanol; H₂O / 2 h / Heating

4: 65 percent / K₂CO₃ / CH₂Cl₂ / 1 h / -78 °C

With potassium hydroxide; lithium; potassium carbonate; In methanol; dichloromethane; water; propionic acid;

DOI:10.1016/S0040-4020(01)83486-4

upstream raw materials:

cholesteryl methyl ether

Downstream raw materials:

7α-hydroxy-3β-methoxyandrost-5-en-17-one

7β-hydroxy-3β-methoxyandrost-5-en-17-one

17β-<2'-(p-Toluenesulfonoxy)ethoxy>androst-5-ene

17β-<2'-(Toluenesulfonoxy)ethoxy>-3-methoxyestra-1,3,5(10)-triene