4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate
CAS No.:1402149-86-3
Molecular Formula:C₃₄H₃₀F₃N₅O₇S₂
Molecular Weight:741.769
Hs Code.:

4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

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Chemical Property of 4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

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Technology Process of 4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

There total 8 articles about 4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311269-20-1
5-[(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

: 1402149-86-3
4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide hydrochloride; triethylamine / methanol; dichloromethane / 3 h / 25 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With ammonium hydroxide hydrochloride; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1021/jm300624s

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 1402149-86-3
4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; dmap / Reflux; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

3.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 80 °C / Inert atmosphere

6.1: ammonium hydroxide hydrochloride; triethylamine / methanol; dichloromethane / 3 h / 25 °C / Inert atmosphere

7.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; ammonium hydroxide hydrochloride; potassium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 5.1: |Suzuki Coupling;
DOI:10.1021/jm300624s

Reference yield:

: 1311269-26-7
(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

: 1402149-86-3
4-{[(3R)-7-(5-cyanofuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

2.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 80 °C / Inert atmosphere

5.1: ammonium hydroxide hydrochloride; triethylamine / methanol; dichloromethane / 3 h / 25 °C / Inert atmosphere

6.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; ammonium hydroxide hydrochloride; potassium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm300624s