Base Information
- Chemical Name:6-fluoro-hexanoyl chloride
- CAS No.:661-00-7
- Molecular Formula:C6H10ClFO
- Molecular Weight:152.596
- Hs Code.:
Synonyms:
Synonyms:
The study focuses on the design, synthesis, and biological evaluation of a novel chemical scaffold, 6,7-dihydro-5H-cyclopenta[d]pyrimidine derivatives, as inhibitors of vascular endothelial growth factor receptor 2 (VEGFR 2). The research involved molecular modeling protocols, including 3D-QSAR pharmacophore modeling, virtual screening, and docking studies, to identify and design potential VEGFR 2 inhibitors. The chemicals used in the study include a series of synthesized 6,7-dihydro-5H-cyclopenta[d]pyrimidine derivatives, with compounds 6c and 6b showing significant enzyme inhibition of 97% and 87% at 10 μM, respectively. These compounds were designed to target the VEGFR 2 receptor, which plays a crucial role in angiogenesis and is a key therapeutic target for inhibiting tumor growth and metastasis. The purpose of these chemicals was to serve as potential anti-cancer agents by inhibiting the VEGFR 2 signaling pathway, thereby affecting the blood supply to tumor cells and inhibiting their growth and spread.
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