1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

Base Information

Chemical Name:1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene
CAS No.:1618093-04-1
Molecular Formula:C₁₆H₂₄BrIO₂
Molecular Weight:455.174
Hs Code.:

Synonyms:

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Chemical Property of 1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

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Technology Process of 1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

There total 12 articles about 1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1618093-03-0
[5-((2-ethylhexyl)oxy)-4-iodo-2-methoxyphenyl]methanol

: 1618093-04-1
1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo501266g

Reference yield:

: 123-31-9,8027-02-9
hydroquinone

: 1618093-04-1
1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 50 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: potassium acetate; bromine / acetic acid / 50 °C / Inert atmosphere

4.1: sodium hydroxide; water / tert-butyl alcohol / Inert atmosphere; Reflux

5.1: triethylamine; magnesium chloride / acetonitrile / Inert atmosphere; Reflux

6.1: toluene-4-sulfonic acid / toluene / Inert atmosphere; Dean-Stark; Reflux

7.1: potassium hydroxide / dimethyl sulfoxide / 40 °C / Inert atmosphere

8.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Glovebox; Inert atmosphere

8.2: -78 - 20 °C / Inert atmosphere

9.1: trifluoroacetic acid / tetrahydrofuran; water / 50 °C / Inert atmosphere

10.1: sodium tetrahydroborate / tetrahydrofuran / 0 °C / Inert atmosphere

11.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; water; bromine; potassium acetate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; magnesium chloride; In tetrahydrofuran; hexane; water; acetic acid; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol; 1.1: |Williamson Ether Synthesis;
DOI:10.1021/jo501266g

Reference yield:

: 1618092-92-4
4-((2-ethylhexyl)oxy)phenyl 4-methylbenzenesulfonate

: 1618093-04-1
1-bromomethyl-5-((2-ethylhexyl)oxy)-4-iodo-2-methoxybenzene

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium acetate; bromine / acetic acid / 50 °C / Inert atmosphere

2.1: sodium hydroxide; water / tert-butyl alcohol / Inert atmosphere; Reflux

3.1: triethylamine; magnesium chloride / acetonitrile / Inert atmosphere; Reflux

4.1: toluene-4-sulfonic acid / toluene / Inert atmosphere; Dean-Stark; Reflux

5.1: potassium hydroxide / dimethyl sulfoxide / 40 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Glovebox; Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / tetrahydrofuran; water / 50 °C / Inert atmosphere

8.1: sodium tetrahydroborate / tetrahydrofuran / 0 °C / Inert atmosphere

9.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; water; bromine; potassium acetate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; magnesium chloride; In tetrahydrofuran; hexane; water; acetic acid; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo501266g