1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1584731-59-8
Molecular Formula:C₃₂H₃₇Cl₂N₃O₅S
Molecular Weight:646.635
Hs Code.:

1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

There total 6 articles about 1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584732-14-8
C₃₄H₄₁Cl₂N₃O₅S

: 1584731-59-8
1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm401911v

Reference yield:

: (5R,6S)-1-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-3-((2-(trimethylsilyl)ethoxy)methyl)piperidin-2-one

: 1584731-59-8
1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: hydrazine / ethanol / 90 °C / Inert atmosphere; Microwave irradiation

4: N,N-dimethyl acetamide / 2 h / 100 °C / Inert atmosphere; Microwave irradiation

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C / Inert atmosphere

With boron trifluoride diethyl etherate; water; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm401911v

Reference yield:

: 1584731-84-9
(3R,5R,6S)-1-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-(hydroxymethyl)-3-methylpiperidin-2-one

: 1584731-59-8
1-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: hydrazine / ethanol / 90 °C / Inert atmosphere; Microwave irradiation

3: N,N-dimethyl acetamide / 2 h / 100 °C / Inert atmosphere; Microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C / Inert atmosphere

With water; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm401911v