N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

Base Information

Chemical Name:N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide
CAS No.:1404098-52-7
Molecular Formula:C₂₆H₂₄F₄N₄O₆S
Molecular Weight:596.559
Hs Code.:

N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

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Chemical Property of N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

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Technology Process of N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

There total 4 articles about N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.2%

: 67-52-7,944357-77-1
BARBITURIC ACID

: 1404097-83-1
N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-formylbenzyl)methanesulfonamide

: 1404098-52-7
N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

Guidance literature:: In ethanol; water; at 80 ℃; Reflux;
DOI:10.1021/jm301164y

Reference yield:

: 115754-21-7
3-fluoro-4-(trifluoromethyl)benzoic acid

: 1404098-52-7
N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 - 25 °C

2: dichloromethane / 3 h / 0 - 25 °C

3: potassium carbonate / ethanol; water / 25 - 80 °C

4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

5: hydrogenchloride / water; acetone / 0.5 h

6: triethylamine / dichloromethane / 20 - 25 °C

7: ethanol; water / 80 °C / Reflux

With hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm301164y

Reference yield:

: C₁₃H₁₄F₄N₂O*C₂HF₃O₂

: 1404098-52-7
N-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol; water / 25 - 80 °C

2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

3: hydrogenchloride / water; acetone / 0.5 h

4: triethylamine / dichloromethane / 20 - 25 °C

5: ethanol; water / 80 °C / Reflux

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm301164y