Technology Process of (2S,3S,6S)-2-{2-[(4R,5S,6R)-6-Isopropyl-5-methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl]-[1,3]dithian-2-yl}-6-((2R,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-heptan-3-ol
There total 18 articles about (2S,3S,6S)-2-{2-[(4R,5S,6R)-6-Isopropyl-5-methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl]-[1,3]dithian-2-yl}-6-((2R,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-heptan-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 18 steps
1: 79 percent / tetrahydrofuran
2: H2 / 10percent Pd-C
3: imidazole / dimethylformamide
4: 61 percent / BF3*OEt2 / acetonitrile
5: 88 percent / Na2PtCl6
6: 96 percent / MCPBA, Na2HPO4
7: tetrahydrofuran / -78 °C
8: TBAF / tetrahydrofuran
9: 95 percent / (PhO)3PMeI / benzene
10: 94 percent / Zn / pyridine; ethanol
11: 93 percent / i-Pr2NEt
12: 1.) OsO4, NMO, 2.) NaIO4 / 2.) THF, H2O
13: n-BuLi / tetrahydrofuran
14: PCC, 4 Angstroem molecular sieves
15: H2 / 10percent Pd-C
16: TsOH / methanol / Heating
17: n-BuLi, BF3*OEt2 / -78 °C
18: Na-Hg
With
1H-imidazole; sodium hexachloroplatinate; sodium periodate; disodium hydrogenphosphate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium amalgam; 4 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1055/s-1997-3257
- Guidance literature:
-
Multi-step reaction with 17 steps
1: H2 / 10percent Pd-C
2: imidazole / dimethylformamide
3: 61 percent / BF3*OEt2 / acetonitrile
4: 88 percent / Na2PtCl6
5: 96 percent / MCPBA, Na2HPO4
6: tetrahydrofuran / -78 °C
7: TBAF / tetrahydrofuran
8: 95 percent / (PhO)3PMeI / benzene
9: 94 percent / Zn / pyridine; ethanol
10: 93 percent / i-Pr2NEt
11: 1.) OsO4, NMO, 2.) NaIO4 / 2.) THF, H2O
12: n-BuLi / tetrahydrofuran
13: PCC, 4 Angstroem molecular sieves
14: H2 / 10percent Pd-C
15: TsOH / methanol / Heating
16: n-BuLi, BF3*OEt2 / -78 °C
17: Na-Hg
With
1H-imidazole; sodium hexachloroplatinate; sodium periodate; disodium hydrogenphosphate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium amalgam; 4 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1055/s-1997-3257
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 percent / i-Pr2NEt
2: 1.) OsO4, NMO, 2.) NaIO4 / 2.) THF, H2O
3: n-BuLi / tetrahydrofuran
4: PCC, 4 Angstroem molecular sieves
5: H2 / 10percent Pd-C
6: TsOH / methanol / Heating
7: n-BuLi, BF3*OEt2 / -78 °C
8: Na-Hg
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium amalgam; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1055/s-1997-3257
