GSK-2881078

Base Information

Chemical Name:GSK-2881078
CAS No.:1539314-06-1
Molecular Formula:C₁₄H₁₃F₃N₂O₂S
Molecular Weight:330.331
Hs Code.:

Synonyms:

Suppliers and Price of GSK-2881078

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSK-2881078
100mg
$ 1805.00

DC Chemicals
GSK2881078 >98%
250 mg
$ 1300.00

Cayman Chemical
GSK2881078 ≥98%
5mg
$ 135.00

Cayman Chemical
GSK2881078 ≥98%
1mg
$ 30.00

Cayman Chemical
GSK2881078 ≥98%
10mg
$ 240.00

Cayman Chemical
GSK2881078 ≥98%
25mg
$ 525.00

Biosynth Carbosynth
GSK 2881078
50 mg
$ 507.50

Biosynth Carbosynth
GSK 2881078
10 mg
$ 145.00

ApexBio Technology
GSK2881078
25mg
$ 705.00

ApexBio Technology
GSK2881078
5mg
$ 182.00

Total 40 raw suppliers

Chemical Property of GSK-2881078

Chemical Property:

Boiling Point:521.6±50.0 °C(Predicted)
Density:1.36±0.1 g/cm3(Predicted)
Solubility.:≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide

Purity/Quality:

99%, ^*data from raw suppliers

GSK-2881078 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK2881078 is a selective androgen receptor modulator (SARM). It induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM), an effect that can be inhibited by the non-steroidal AR antagonist bicalutamide .
Uses GSK 2881078 is a selective androgen receptor modulator which can display agonistic properties in anabolic target tissues

Technology Process of GSK-2881078

There total 10 articles about GSK-2881078 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1539314-87-8
(R)-1-(1-(methylthio)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

: 1539314-06-1
(R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: With ozone; In methanol; water; for 0.833333h;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1539314-06-1
(R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -45 °C

1.2: 1 h / -70 - -52 °C

2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 0.17 h / Sealed tube; Sonication

2.2: 60 °C / Sonication

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.83 h / 100 °C / Sealed tube

4.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.67 h / 50 °C

5.1: ozone / methanol; water / 0.83 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; ozone; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: C₁₇H₂₁F₃N₂SSi

: 1539314-06-1
(R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.67 h / 50 °C

2: ozone / methanol; water / 0.83 h

With potassium tert-butylate; ozone; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water;