Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

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Chemical Name:Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide
CAS No.:776301-50-9
Molecular Formula:C₃₃H₃₂N₄O₆S₂
Molecular Weight:644.772
Hs Code.:

Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

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Chemical Property of Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

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Technology Process of Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

There total 11 articles about Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244081-35-4
(R)-3-(2-aminopropyl)-7-benzyloxyindole

: 776301-50-9
Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / CHCl₃

2: 99 percent / HCO₂NH₄ / Pd/C / methanol

3: 29 percent / Ph₃P; DEAD / tetrahydrofuran

4: HCl / ethyl acetate

5: i-PrNEt₂; KI / acetonitrile

6: HCl / ethanol

With hydrogenchloride; N,N-diethyl-N-isopropylamine; ammonium formate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; ethyl acetate; acetonitrile; 3: Mitsunobu alkylation;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 244081-38-7
(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole

: 776301-50-9
Thiophene-2-sulfonic acid {3-[(R)-2-((R)-2-{7-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-1H-indol-3-yl}-1-methyl-ethylamino)-1-hydroxy-ethyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / HCO₂NH₄ / Pd/C / methanol

2: 29 percent / Ph₃P; DEAD / tetrahydrofuran

3: HCl / ethyl acetate

4: i-PrNEt₂; KI / acetonitrile

5: HCl / ethanol

With hydrogenchloride; N,N-diethyl-N-isopropylamine; ammonium formate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; ethyl acetate; acetonitrile; 2: Mitsunobu alkylation;
DOI:10.1016/j.bmcl.2004.10.035