cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²

Base Information

• Chemical Name: cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²
• CAS No.: 1158176-25-0
• Molecular Formula: C₆₁H₁₁₀N₂₆O₁₄
• Molecular Weight: 1431.71
• Mol file: 1158176-25-0.mol

Synonyms:

Chemical Property of cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²

There total 1 articles about cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹² which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclic Fmoc-Arg(Tos)-Arg(Tos)-Arg(Tos)-Thr(Bzl)-Dab(2-CIZ)-Dab-Dab(2-CIZ)-D-Phe-Leu-Dab(2-CIZ)-Dab(2-CIZ)-Thr(Bzl), containing amide bond between γ-NH2 of Dab6 and α-COOH of Thr12 (1173986-62-3) → cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab6 and α-COOH of Thr12 (1158176-25-0)

Guidance literature:

cyclic Fmoc-Arg(Tos)-Arg(Tos)-Arg(Tos)-Thr(Bzl)-Dab(2-CIZ)-Dab-Dab(2-CIZ)-D-Phe-Leu-Dab(2-CIZ)-Dab(2-CIZ)-Thr(Bzl), containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²; With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With hydrogen fluoride; methoxybenzene; for 1h; Cooling with ice;

DOI:10.1248/cpb.57.332

Reference yield:

cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr, containing amide bond between γ-NH2 of Dab6 and α-COOH of Thr12 (1158176-25-0) → cyclic Arg-Arg-Arg-Thr-Dab-Dab-Dab-D-Phe-Leu-Dab-Dab-Thr hydrochloride, containing amide bond between γ-NH2 of Dab6 and α-COOH of Thr12

Guidance literature:

With hydrogenchloride; In water; acetonitrile;

DOI:10.1248/cpb.57.332

upstream raw materials:

cyclic Fmoc-Arg(Tos)-Arg(Tos)-Arg(Tos)-Thr(Bzl)-Dab(2-CIZ)-Dab-Dab(2-CIZ)-D-Phe-Leu-Dab(2-CIZ)-Dab(2-CIZ)-Thr(Bzl), containing amide bond between γ-NH2 of Dab⁶ and α-COOH of Thr¹²