isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

Base Information

Chemical Name:isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate
CAS No.:121506-13-6
Molecular Formula:C₃₇H₅₃N₃O₇
Molecular Weight:651.844
Hs Code.:

isopropyl (2R,3S)-3-<N-((2R)-4-morpholinocarbonyl-2-(1-naphthylmethyl)proponyl)-L-valyl>amino-4-cyclohexyl-2-hydroxybutyrate

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Chemical Property of isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

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Technology Process of isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

There total 4 articles about isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 121506-13-6,132016-56-9
isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / acetonitrile / 2 h / 0 °C / 2) ambient temperature, overnight

2: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1248/cpb.38.2487

Reference yield:

: 119434-65-0
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionic acid

: 121506-13-6,132016-56-9
isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / acetonitrile / 2 h / 0 °C / 2) ambient temperature, overnight

2: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1248/cpb.38.2487

Reference yield:

: 98105-43-2
(3S)-3-hydroxy-(4S)-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanoic acid ethyl ester

: 121506-13-6,132016-56-9
isopropyl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / HCl / 2 h / 80 °C

2: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide;
DOI:10.1248/cpb.38.2487