C₂₂H₂₁ClN₂O₃

Base Information

• Chemical Name: C₂₂H₂₁ClN₂O₃
• CAS No.: 1181964-91-9
• Molecular Formula: C₂₂H₂₁ClN₂O₃
• Molecular Weight: 396.873
• Mol file: 1181964-91-9.mol

Synonyms:

Chemical Property of C₂₂H₂₁ClN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁ClN₂O₃

There total 5 articles about C₂₂H₂₁ClN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H25ClN2O3 → C22H21ClN2O3 (1181964-91-9)

Guidance literature:

With ethanol; sodium hydroxide; In tetrahydrofuran; at 50 ℃;

DOI:10.1016/j.bmcl.2011.01.094

Reference yield:

α-picoline (109-06-8) → C22H21ClN2O3 (1181964-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -80 - -20 °C

1.2: Reflux

2.1: trichlorophosphate / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / Molecular sieve

4.1: ethanol; sodium hydroxide / tetrahydrofuran / 50 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; 2.1: Vilsmeier formylation;

DOI:10.1016/j.bmcl.2011.01.094

Reference yield:

ethyl 4-oxo-4H-quinolizine-3-carboxylate (88612-71-9) → C22H21ClN2O3 (1181964-91-9)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / Molecular sieve

3: ethanol; sodium hydroxide / tetrahydrofuran / 50 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Vilsmeier formylation;

DOI:10.1016/j.bmcl.2011.01.094

upstream raw materials:

α-picoline

ethyl 4-oxo-4H-quinolizine-3-carboxylate

1-formyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester