(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

Base Information

Chemical Name:(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester
CAS No.:110627-15-1
Molecular Formula:C₂₇H₃₁N₃O₅S
Molecular Weight:509.626
Hs Code.:

(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

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Chemical Property of (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

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Technology Process of (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

There total 3 articles about (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.4%

: 40439-01-8
hetacillin

: 3587-60-8
Benzyloxymethyl chloride

: 110627-15-1
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 5h; 1.) 0-5 deg C, 5 h, 2.) RT;
DOI:10.1248/cpb.35.2366

Reference yield:

: 33993-48-5
ampicillin

: 110627-15-1
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41.3 percent / 6M NaOH / H₂O / 1.) 35-40 deg C, 3 h, 2.) RT

2: 49.4 percent / Et₃N / CH₂Cl₂ / 5 h / 1.) 0-5 deg C, 5 h, 2.) RT

With sodium hydroxide; triethylamine; In dichloromethane; water;
DOI:10.1248/cpb.35.2366

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 110627-15-1
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyloxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / CaCl₂, HCl / H₂O / 6 h / 5 °C

2: 49.4 percent / Et₃N / CH₂Cl₂ / 5 h / 1.) 0-5 deg C, 5 h, 2.) RT

With hydrogenchloride; triethylamine; calcium chloride; In dichloromethane; water;
DOI:10.1248/cpb.35.2366