C₁₈H₂₁ClN₂O₃

Base Information

• Chemical Name: C₁₈H₂₁ClN₂O₃
• CAS No.: 1333869-86-5
• Molecular Formula: C₁₈H₂₁ClN₂O₃
• Molecular Weight: 348.829
• Mol file: 1333869-86-5.mol

Synonyms:

Chemical Property of C₁₈H₂₁ClN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₁ClN₂O₃

There total 5 articles about C₁₈H₂₁ClN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (625470-33-9) → C18H21ClN2O3 (1333869-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

2: methanol; sodium hydroxide

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Suzuki reaction;

DOI:10.1016/j.bmcl.2011.06.117

Reference yield:

C11H8ClNO3 (1333869-51-4) → C18H21ClN2O3 (1333869-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium hydroxide

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

With methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.06.117

Reference yield:

5-bromo-2-chlorobenzoic acid (21739-92-4) → C18H21ClN2O3 (1333869-86-5)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / water

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / Heating

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

4: methanol; sodium hydroxide

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: Suzuki reaction;

DOI:10.1016/j.bmcl.2011.06.117

upstream raw materials:

methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

C₁₁H₈ClNO₃

1-(aminomethyl)cycloheptanol

C₁₀H₆ClNO₃