(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Base Information

Chemical Name:(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide
CAS No.:1268881-20-4
Molecular Formula:C₁₈H₂₃N₅O₃
Molecular Weight:357.412
Hs Code.:

(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Synonyms:

Suppliers and Price of (1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
APD371
1mg
$ 60.00

ChemScene
Olorinab ≥99.0%
10mg
$ 450.00

ChemScene
Olorinab ≥99.0%
5mg
$ 250.00

ChemScene
Olorinab ≥99.0%
100mg
$ 1950.00

ChemScene
Olorinab ≥99.0%
50mg
$ 1350.00

ChemScene
Olorinab ≥99.0%
25mg
$ 850.00

Chemenu
(2S,4S)-N-[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]-9-(4-oxidopyrazin-4-ium-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide 95%+
10mg
$ 796.00

Biosynth Carbosynth
APD 371 NEW
10 mg
$ 175.00

Biosynth Carbosynth
APD 371 NEW
50 mg
$ 612.50

AK Scientific
(2S,4S)-N-[(2S)-1-Hydroxy-3,3-dimethylbutan-2-yl]-9-(4-oxidopyrazin-4-ium-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
50mg
$ 876.00

Total 5 raw suppliers

Chemical Property of (1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Chemical Property:

Boiling Point:636.6±55.0 °C(Predicted)
Density:1.49±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

APD371 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

There total 9 articles about (1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.9%

: 1268883-00-6
3-((4aS,5aS)-3-carboxy-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazol-1-yl)pyrazine 1-oxide

: 112245-13-3
(S)-tert-leucinol

: 1268881-20-4
(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Guidance literature:: 3-((4aS,5aS)-3-carboxy-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazol-1-yl)pyrazine 1-oxide; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 0 - 5 ℃; for 0.75h; Large scale;

(S)-tert-leucinol; In acetonitrile; at 0 - 5 ℃; Large scale;

Reference yield:

: 1268881-17-9
(4aS,5aS)-N-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-1-(pyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide

: 1268881-20-4
(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 - 23 ℃; for 21h;

Reference yield:

: 196488-92-3
(1S,5R)-bicyclo[3.1.0]hexan-2-one

: 1268881-20-4
(1aS,5aS)-2-(4-oxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diazacyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethylpropyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / ethanol; tetrahydrofuran / 3.75 h / 40 °C

1.2: 1.5 h / 50 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 h / 23 °C

3.1: formic acid; dihydrogen peroxide / water / 4 h / 20 - 64 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 23 °C

With formic acid; potassium tert-butylate; water; dihydrogen peroxide; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;