4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone

Base Information

• Chemical Name: 4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone
• CAS No.: 6342-46-7
• Molecular Formula: C13H10 Cl N3 O
• Molecular Weight: 259.695
• Hs Code.: 2933399090
• European Community (EC) Number: 688-754-2
• NSC Number: 50111
• Nikkaji Number: J1.026.716A
• Mol file: 6342-46-7.mol

Synonyms:4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone;N-[(Z)-(4-chlorophenyl)methylideneamino]pyridine-4-carboxamide;6342-46-7;NSC50111;NSC-50111

Chemical Property of 4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone

Chemical Property:

• PSA: 54.35000
• Density: 1.26g/cm3
• LogP: 2.88980
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 259.0512396
• Heavy Atom Count: 18
• Complexity: 295

Purity/Quality:

98%,99%, ^*data from raw suppliers

ISONICOTINIC ACID (4-CHLORO-BENZYLIDENE)-HYDRAZIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=NNC(=O)C2=CC=NC=C2)Cl
• Isomeric SMILES: C1=CC(=CC=C1/C=N\NC(=O)C2=CC=NC=C2)Cl

Technology Process of 4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone

There total 2 articles about 4-Chlorobenzaldehyde (4-pyridylcarbonyl)hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isoniazid (54-85-3,7640-37-1) + 4-chlorobenzaldehyde (104-88-1) → (E)-N′-(4′-chlorobenzylidene)isonicotinohydrazide (6342-46-7)

Guidance literature:

In ethanol; water; at 20 ℃; for 0.0833333h; UV-irradiation;

DOI:10.2174/1570178613666160824123827

Reference yield: 98.1%

isoniazid (54-85-3,7640-37-1) + 4-chlorobenzaldehyde (104-88-1) → N'-[(Z)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide (6342-46-7)

Guidance literature:

In water; Microwave irradiation;

DOI:10.5012/jkcs.2011.55.6.960

Reference yield: 96.8%

N'-[(Z)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide (6342-46-7) + mercaptoacetic acid (68-11-1) → N-[2-(4-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide (79844-21-6)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; Molecular sieve; Sonication;

DOI:10.5012/jkcs.2011.55.6.960

upstream raw materials:

isoniazid

4-chlorobenzaldehyde

Downstream raw materials:

pyridine-4-methanol

4-chlorobenzylamine

2-(4-chlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole

N-[2-(4-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide