(5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione

Base Information

• Chemical Name: (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione
• CAS No.: 118967-81-0
• Molecular Formula: C₉H₁₃FN₂O₆
• Molecular Weight: 264.21
• Mol file: 118967-81-0.mol

Synonyms:

Chemical Property of (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione

There total 3 articles about (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-deoxyuridine (15958-99-3) → (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione (118967-81-0,119066-20-5) + Acetic acid (4R,5S)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + Acetic acid (4S,5R)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + doxifluridine (69260-71-5,71609-07-9,71609-60-4,76462-79-8,106775-49-9,106775-50-2,106775-51-3,3094-09-5)

Guidance literature:

With acetyl hypofluorite; In acetic acid; Further byproducts given. Yields of byproduct given;

DOI:10.1039/P19880002547

Reference yield:

5'-deoxyuridine (15958-99-3) → (5S,6R)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione (118967-81-0,119066-20-5) + Acetic acid (4R,5S)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + Acetic acid (4S,5R)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + doxifluridine (69260-71-5,71609-07-9,71609-60-4,76462-79-8,106775-49-9,106775-50-2,106775-51-3,3094-09-5)

Guidance literature:

With acetyl hypofluorite; In water; Yield given. Further byproducts given. Yields of byproduct given;

DOI:10.1039/P19880002547

Reference yield:

acetyl hypofluorite (78948-09-1) + 5'-deoxyuridine (15958-99-3) → (5R,6S)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-6-hydroxy-dihydro-pyrimidine-2,4-dione (118967-81-0,119066-20-5) + Acetic acid (4R,5S)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + Acetic acid (4S,5R)-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-fluoro-2,6-dioxo-hexahydro-pyrimidin-4-yl ester (118967-80-9,119066-19-2) + doxifluridine (69260-71-5,71609-07-9,71609-60-4,76462-79-8,106775-49-9,106775-50-2,106775-51-3,3094-09-5)

Guidance literature:

In acetic acid; Yield given. Further byproducts given. Yields of byproduct given;

DOI:10.1039/P19880002547

upstream raw materials:

5'-deoxyuridine

acetyl hypofluorite