VU 0365114

Base Information

• Chemical Name: VU 0365114
• CAS No.: 1208222-39-2
• Molecular Formula: C₂₂H₁₄F₃NO₃
• Molecular Weight: 397.353
• Mol file: 1208222-39-2.mol

Synonyms:

Chemical Property of VU 0365114

Chemical Property:

• Boiling Point: 526.2±60.0 °C(Predicted)
• PKA: -3.71±0.20(Predicted)
• Density: 1.386±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

VU 0365114 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).

Technology Process of VU 0365114

There total 1 articles about VU 0365114 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H9BrF3NO3 (1160247-88-0) + phenylboronic acid (98-80-6) → V(651)U0314 (1208222-39-2)

Guidance literature:

With bis[tris( 1,1-dimethylethyl)phosphine]-palladium; caesium carbonate; In tetrahydrofuran; water; at 120 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.bmcl.2009.11.089

upstream raw materials:

C₁₆H₉BrF₃NO₃

phenylboronic acid